Apoptosis induced in JURKAT human T cell leukemia cell line by soluble recombinant human TRAIL is completely blocked by anti-human TRAIL (2E5). The neutralizing activity of the antibody 2E5 has been confirmed with various sources of soluble recombinant human TRAIL. A - medium B - recombinant TRAIL C - recombinant TRAIL + anti-human TRAIL (2E5; 0.06 ug/ml) D - recombinant TRAIL + anti-human TRAIL (2E5; 0.24 ug/ml) E - recombinant TRAIL + Isotype mouse IgG1 controlE - recombinant TRAIL + Isotype mouse IgG1 control