| MW: | 40kDa |
| Purity: | >95% as determined by SDS-PAGE |
| Description: | Human CD30/TNFRSF8 protein, His tag (Animal-Free), expressed in HEK 293 Cells |
| Further Information: | CD30 is a member of the tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), and its normal expression is restricted to activated T and B cells. In tumor cells, CD30 expression is most commonly associated with lymphoid malignancies (Hodgkin and non-Hodgkin lymphomas) and is a therapeutic target using anti-CD30 antibody. CD30 expression has been reported also in mostly adult non-lymphoid malignancies, raising the possibility of CD30-targeted therapy for additional tumors. CD30 is normally not expressed by mast cells, which regulates proliferation/apoptosis and antibody responses. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. |
| NCBI EntrezGene: | 943 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Lyophilized Human CD30/TNFRSF8 protein, His tag (Animal-Free)should be stored desiccated below -20 C. Upon reconstitution, the protein should be stored at 4 C between 2-7 days and for future use below -20 C. For long term storage it is recommended to add a carrier protein (0.113% HSA or BSA). Please prevent freeze-thaw cycles. |
| Usage: | Research use only |
