| MW: | 56.9 kDa |
| Purity: | >90% as determined by SDS-PAGE |
| Description: | Human CD19 protein, Fc tag (Animal-Free), expressed in HEK 293 Cells |
| Further Information: | CD19 is a B-lineage-specific transmembrane glycoprotein, the expression of which is maintained on more than 95% B-cell malignancies. This strict lineage restriction makes CD19 an ideal target for immune therapies using chimeric antigen receptors (CARs). In normal cells, it is the most ubiquitously expressed protein in the B lymphocyte lineage. CD19 expression is induced at the point of B lineage commitment during the differentiation of the hematopoietic stem cell, and its expression continues through preB and mature B cell differentiation until it is finally down-regulated during terminal differentiation into plasma cells. CD19 expression is maintained in B-lineage cells that have undergone neoplastic transformation, and therefore CD19 is useful in diagnosis of leukemias and lymphomas using monoclonal antibodies (mAbs) and flow cytometry. |
| NCBI EntrezGene: | 930 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Lyophilized Human CD19 protein, Fc tag (Animal-Free)should be stored desiccated below -20 C. Upon reconstitution, the protein should be stored at 4 C between 2-7 days and for future use below -20 C. For long term storage it is recommended to add a carrier protein (0.109% HSA or BSA). Please prevent freeze-thaw cycles. |
| Usage: | Research use only |
