| MW: | 38 kDa |
| Purity: | >95% as determined by SDS-PAGE |
| Description: | Human CD3E protein, Fc tag (Animal-Free), expressed in HEK 293 Cells |
| Further Information: | CD3E is a one-way type I membrane glycoprotein on the surface of t cells. As a Part of the TCR-CD3 complex present on T-lymphocyte cell surface, CD3E plays an essential role in adaptive immune response. CD3E contains one Ig-like domain and one ITAM domain. CD3E together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/? and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition with a variety of intracellular signal transduction pathways. Polypeptides play an important role in T cell development. CD3E molecules play a crucial role in T cell development, and CD3e gene deficiency can lead to severe immune deficiency. The CD3E gene is also associated with a woman's susceptibility to type I diabetes. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2. The CD3 co-receptor complex is essential for signal transduction after specific binding of the T-cell receptor (TCR). |
| NCBI EntrezGene: | 916 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Lyophilized Human CD3E protein, Fc tag (Animal-Free)should be stored desiccated below -20 C. Upon reconstitution, the protein should be stored at 4 C between 2-7 days and for future use below -20 C. For long term storage it is recommended to add a carrier protein (0.108% HSA or BSA). Please prevent freeze-thaw cycles. |
| Usage: | Research use only |
