| Applications: | WB, IHC, ICC, IF, IP, ELISA |
| Species Reactivity: | Human, Mouse, Rat, Eukaryote |
| Dilutions: | The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user. |
| Isotype: | Rabbit IgG |
| Immunogen: | Synthetic molecular mimic of soluble oligomers |
| Purification: | Protein A Purified |
| Conjugation: | HRP |
| Description: | Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3). |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
