Mitofusin 2, Monoclonal Antibody
Partner: Aviva Systems Biology
| Applications: | WB, IHC, ICC, IF |
| Species Reactivity: | Human, Mouse, Rat |
| Dilutions: | WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user. |
| Immunogen: | Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1. |
| Purification: | Protein G Purified |
| Conjugation: | Unconjugated |
| Description: | Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression. |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
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