Data Sheet

DUX4, Monoclonal Antibody

Applications:	WB, IHC, ICC, IF
Species Reactivity:	Human, Mouse
Dilutions:	WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Immunogen:	C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag
Purification:	Protein G Purified
Conjugation:	Unconjugated
Description:	DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only