Data Sheet

MSDS

BMS-986260 [CAS 2001559-19-7]

CAS No:	2001559-19-7
Applications:	COVID-19-immunoregulation
MW:	382.78
Formula:	C₁₈H₁₂ClFN₆O
SMILES:	N#CC1=CN=C2C=CC(C3=C(C4=CC=C(F)C(Cl)=C4)N=CN3CCO)=NN21
Purity:	98.03
Description:	BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGF?R1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGF?R1 over its isozyme TGF?R2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGF? mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only