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Cat Number:HY-P99395-1mg
Size:1mg
Price:£574.00
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Shipping:£20.00

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Talacotuzumab [CAS 1826831-79-1]

Partner: MedChemexpress LLC

CAS No:1826831-79-1
Applications:Cancer-programmed cell death
MW:N/A
Formula:N/A
SMILES:[Talacotuzumab]
Purity:95.00
Description:Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (Fc?RIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models[1][2][3][4].
Shipping Conditions:Ship on dry ice
Usage:Research Use Only

 

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