Elezanumab [CAS 1791416-49-3]
Partner: MedChemexpress LLC
| CAS No: | 1791416-49-3 |
| Applications: | Metabolism-protein/nucleotide metabolism |
| MW: | N/A |
| Formula: | N/A |
| SMILES: | [Elezanumab] |
| Purity: | 99.69 |
| Description: | Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism[1][2]. |
| Shipping Conditions: | Ship on dry ice |
| Usage: | Research Use Only |
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