| Description: | UbcH7/UBE2L3, a distinctive ubiquitin-conjugating enzyme E2, collaborates with HECT-type and RBR family E3 ligases, lacking intrinsic E3-independent reactivity with lysine. It uniquely works with RBR family E3 enzymes like PRKN, RNF31, and ARIH1, acting like RING-HECT hybrids. Downstream of E1, UbcH7 catalyzes ubiquitin attachment, facilitating 'Lys-11'-linked polyubiquitination. Its involvement in selective protein degradation supports cellular quality control, and down-regulation in S-phase suggests a role in cell cycle progression. Additionally, it affects nuclear hormone receptors' transcriptional activity, contributing to myelopoiesis. UbcH7/UBE2L3 Protein, Human is the recombinant human-derived UbcH7/UBE2L3 protein, expressed by E. coli, with tag free. The total length of UbcH7/UBE2L3 Protein, Human is 154 a.a., with molecular weight of ~18 kDa. |
