| Description: | IFN-gamma (Interferon-gamma), a type II interferon produced by immune cells like T-cells and NK cells, crucially activates antimicrobial, antiviral, and antitumor responses. Its primary JAK-STAT signaling pathway, triggered by interaction with receptor IFNGR1, influences gene regulation. Upon IFN-gamma binding, IFNGR1 intracellular domain unfolds, activating downstream components (JAK2, JAK1, STAT1), leading to STAT1 activation, transcription of IFNG-regulated genes, and further transcriptional regulation by induced factors like IRF1. IFN-gamma enhances class I antigen presentation, boosts peptide generation efficiency, up-regulates MHC II complexes, and participates in hematopoietic stem cell regulation. As a homodimer, IFN-gamma interacts with IFNGR1 extracellularly, crucial for diverse immune and hematopoietic functions. IFN-gamma Protein, Feline is the recombinant IFN-gamma protein, expressed by E. coli, with tag free. The total length of IFN-gamma Protein, Feline is 144 a.a., with molecular weight of ~17.1 kDa. |
