| Description: | BRD4 protein, a chromatin reader, crucially recognizes and binds acetylated histones, transmitting epigenetic memory and regulating transcription across cell divisions. It associates with acetylated chromatin throughout the cell cycle, maintaining chromatin structure and contributing to epigenetic memory. BRD4 regulates signal-inducible gene transcription during interphase, collaborating with JMJD6 to recruit the P-TEFb complex to enhancers. It also acts as a protein kinase, phosphorylating RNA polymerase II. Beyond histones, BRD4 recognizes acetylated RELA, activating NF-kappa-B. Additionally, it functions in the p53 pathway and acts as a chromatin insulator in the DNA damage response, inhibiting signaling. These diverse functions highlight BRD4's versatile role in epigenetic regulation, transcriptional control, and chromatin maintenance. BRD4 Protein, Human (His-Flag) is the recombinant human-derived BRD4 protein, expressed by E. coli, with N-10*His, N-Flag labeled tag. The total length of BRD4 Protein, Human (His-Flag) is 412 a.a., with molecular weight of 55-60 kDa. |
