| Description: | In the Hippo signaling pathway, MOB4A/MOB1B, a crucial activator, controls organ size and suppresses tumors by regulating proliferation and promoting apoptosis. This pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, with the regulatory protein SAV1, activate LATS1/2. In partnership with its regulator MOB1B, LATS1/2 phosphorylates and inactivates YAP1 and WWTR1/TAZ, influencing gene expression. MOB4A/MOB1B stimulates STK38L and interacts with LATS1 and LATS2, contributing to the complex regulatory network within the Hippo signaling pathway. MOB4A/MOB1B Protein, Human (His) is the recombinant human-derived MOB4A/MOB1B protein, expressed by E. coli, with N-6*His labeled tag. The total length of MOB4A/MOB1B Protein, Human (His) is 216 a.a., with molecular weight of 43-48 kDa. |
