| Description: | IL-18R alpha�(interleukin-18 receptor alpha) is an interleukin receptor of the immunoglobulin superfamily. IL-18 forms a signalling complex with the IL-18 receptor ? (R?) and ? (R?) chains at the plasma membrane, which induces multiple inflammatory cytokines[1]. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor k?- inducing kinase, with subsequent activation of nuclear factor k?[2]. IL-18R alpha�inhibits the production of IFN-? stimulated with the combination of rhIL-2 and rhIL-18[3]. IL-18R alpha Protein, Rhesus macaque (HEK293, Fc) is a recombinant protein with a Fc label that consists of 315 amino acids (M1-K315) and is produced by HEK293 cells. |
