| Description: | PLK1, a serine/threonine-protein kinase, centrally orchestrates critical functions in the M phase of the cell cycle. It regulates centrosome maturation, spindle assembly, cohesin removal, inactivates APC/C inhibitors, and governs mitotic exit and cytokinesis. Phosphorylating a vast array of substrates, including BORA, CCNB1, FOXM1, and others, PLK1's roles include promoting centrosome functions, bipolar spindle assembly, and governing mitotic exit and cytokinesis. It also regulates kinetochore functions, sister chromatid cohesion, and various checkpoint proteins, positioning it as a key player in cell cycle progression. PLK1 Protein, Human (sf9, His) is the recombinant human-derived PLK1 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of PLK1 Protein, Human (sf9, His) is 603 a.a., with molecular weight of ~66 kDa. |
