| Description: | PIN1 Protein, a peptidyl-prolyl cis/trans isomerase, intricately modulates diverse cellular processes by binding to and isomerizing phosphorylated Ser/Thr-Pro motifs. This molecular switch induces conformational changes in phosphorylated proteins, impacting mitosis, kinase activities, oncogene transactivation, centrosome amplification, and cell transformation. Additionally, PIN1 regulates RAF1 dephosphorylation, targets PML and BCL6 for degradation, disrupts FBXW7 dimerization in the JNK cascade, and influences the balance between error-prone NHEJ and error-free HR in DNA repair. During IL33-induced lung inflammation, PIN1 catalyzes cis-trans isomerization of phosphorylated IRAK3, contributing to IRAK3 stabilization, nuclear translocation, and pro-inflammatory gene expression in dendritic cells. PIN1 Protein, Human (His) is the recombinant human-derived PIN1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of PIN1 Protein, Human (His) is 163 a.a., with molecular weight of ~19 kDa. |
