| Description: | SLAMF6 protein, a self-ligand receptor in the SLAM family, intricately regulates immune cell activation and differentiation through homo- or heterotypic interactions, influencing both innate and adaptive immune responses. It relies on cytoplasmic adapters like SH2D1A/SAP and/or SH2D1B/EAT-2 for activity control. In NK cells, SLAMF6 triggers cytolytic activity, requiring VAV1 phosphorylation. It collaborates with SLAMF1 in thymocytic NKT cell lineage development and promotes Th17 differentiation. SLAMF6 may act as a negative regulator in humoral immune responses, negatively signaling CD4(+) T-cells and NKT cells in the absence of SH2D1A/SAP. Conflicting reports suggest its role in T-cell adhesion and B-cell tolerance. Furthermore, SLAMF6 is implicated in autoimmunity regulation, and isoform 3 may suppress pathogenic T-cell proliferation, forming homodimers and interacting with PTN6, PTN11, and SH2D1A/SAP upon phosphorylation. SLAMF6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SLAMF6 protein, expressed by HEK293, with C-His labeled tag. The total length of SLAMF6 Protein, Mouse (HEK293, His) is 209 a.a., with molecular weight of ~28-50 kDa. |
