| Description: | The GSTA1 Protein serves as a glutathione S-transferase, catalyzing the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a broad spectrum of both exogenous and endogenous compounds (Probable). This enzymatic activity includes the formation of glutathione conjugates for prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Additionally, GSTA1 plays a role in hormone biosynthesis by catalyzing the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione (PubMed:11152686). Notably, its glutathione-dependent peroxidase activity extends to the metabolism of oxidized linoleic acid, specifically targeting the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE (PubMed:16624487). The diverse enzymatic functions of GSTA1 underscore its involvement in crucial cellular processes, from detoxification reactions to hormone biosynthesis and the metabolism of oxidized lipids. GSTA1 Protein, Human (HEK293, His, solution) is the recombinant human-derived GSTA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of GSTA1 Protein, Human (HEK293, His, solution) is 222 a.a., with molecular weight of ~26 kDa. |
