| Description: | MST1/STK4 protein, a stress-activated kinase, is pivotal in the Hippo signaling pathway, inducing apoptosis and regulating hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, contributing to chromatin condensation and DNA fragmentation. In the Hippo cascade with SAV1, it activates LATS1/2-MOB1, inhibiting YAP1 and WWTR1/TAZ to control proliferation, cell death, and migration genes. MST1/STK4, vital in repressing hepatocyte proliferation, phosphorylates substrates like FOXO3 and inhibits PKB/AKT1, intersecting with AR activity and promoting p53-dependent transcription in response to DNA damage. MST1/STK4 Protein, Human (sf9, His) is the recombinant human-derived MST1/STK4 protein, expressed by Sf9 insect cells, with N-10*His labeled tag. The total length of MST1/STK4 Protein, Human (sf9, His) is 486 a.a., with molecular weight of ~58 kDa. |
