Description: | PHGDH protein assumes a pivotal role in cellular metabolism by catalyzing the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, marking the initial step in the phosphorylated L-serine biosynthesis pathway. Beyond its involvement in serine biosynthesis, PHGDH exhibits versatile enzymatic activities, including the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. This multifunctional capability underscores the enzyme's significance in the interconnected metabolic pathways governing amino acid biosynthesis and intermediary metabolism. PHGDH's role in orchestrating key steps in these processes highlights its essential contribution to cellular homeostasis and underscores its potential as a therapeutic target in various pathological conditions. PHGDH Protein, Human (C-His) is the recombinant human-derived PHGDH protein, expressed by E. coli , with C-6*His labeled tag. The total length of PHGDH Protein, Human (C-His) is 533 a.a., with molecular weight of ~57 kDa. |