| Description: | SIRP alpha V4/CD172a Protein, an immunoglobulin-like cell surface receptor for CD47, acts as a docking protein, facilitating the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports adhesion of cerebellar neurons, promotes neurite outgrowth, and facilitates glial cell attachment. Engaging in negative regulation, it modulates receptor tyrosine kinase-coupled responses, phagocytosis, mast cell activation, and dendritic cell activation. CD47 binding prevents dendritic cell maturation, inhibits cytokine production, and limits new world arenavirus infection. SIRP alpha V4/CD172a also participates in ROS signaling, interacting with THBS1 and various proteins. SIRP alpha/CD172a Protein, Human (G75A, HEK293, His) is the recombinant human-derived SIRP alpha/CD172a protein, expressed by HEK293 , with C-His labeled tag and G75A mutation. The total length of SIRP alpha/CD172a Protein, Human (G75A, HEK293, His) is 340 a.a., with molecular weight of 45-55 kDa. |
