| Description: | 15-Lipoxygenase 2 (15-LOX2) is a non-heme iron-containing dioxygenase crucial for peroxidation of polyunsaturated fatty acids (PUFAs). It exhibits peroxidase activity on arachidonate and linoleate, producing bioactive lipid mediators. Oxygenating arachidonyl derivatives, it generates 15-HETE-G, a peroxisome proliferator-activated receptor alpha agonist. 15-LOX2 class-switches pro-inflammatory mediators, participates in DHA oxidations to produce specialized pro-resolving mediators, and may influence cell cycle progression, proliferation, cytokine secretion, and macrophage differentiation. Importantly, it shows substrate specificity by not converting arachidonic acid to (15S)-HPETE. 15 Lipoxygenase 2 Protein, Human (sf9) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of 15 Lipoxygenase 2 Protein, Human (sf9) is 676 a.a., with molecular weight of 62-66 kDa. |
