| Description: | AGO1 Protein is essential for RNA-mediated gene silencing (RNAi) by binding to short RNAs like microRNAs (miRNAs) or short interfering RNAs (siRNAs) and suppressing the translation of complementary mRNAs. Although lacking endonuclease activity, AGO1 does not cleave target mRNAs. It is also vital for transcriptional gene silencing (TGS) of promoter regions complementary to bound short antigene RNAs (agRNAs). AGO1 interacts with various proteins such as DDB1, DDX5, DICER1, AGO2, and more, associating with polysomes and messenger ribonucleoproteins (mNRPs). Additionally, it engages with LIMD1, WTIP, AJUBA, and APOBEC3 proteins. AGO1 Protein, Human (sf9, His) is the recombinant human-derived AGO1 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of AGO1 Protein, Human (sf9, His) is 857 a.a., with molecular weight of ~99.5 kDa. |
