| Description: | Cyclophilin F/PPIF Protein, a peptidyl-prolyl cis-trans isomerase (PPIase), catalyzes proline imidic peptide bond isomerization, potentially aiding in protein folding. It crucially regulates the mitochondrial permeability transition pore (mPTP), influencing apoptosis or necrosis. Collaborating with mitochondrial p53/TP53, it activates oxidative stress-induced necrosis and modulates mitochondrial membrane F(1)F(0) ATP synthase activity. Cyclophilin F/PPIF, with BCL2, inhibits cytochrome c-dependent apoptosis independently of the mPTP, highlighting its diverse roles in mitochondrial function and cell survival mechanisms. Cyclophilin F/PPIF Protein, Human (HEK293, His) is the recombinant human-derived Cyclophilin F/PPIF protein, expressed by HEK293, with C-6*His labeled tag. The total length of Cyclophilin F/PPIF Protein, Human (HEK293, His) is 178 a.a., with molecular weight of ~24-34 kDa. |
