| Description: | p38 alpha/MAPK14 Protein, a vital serine/threonine kinase in the MAP kinase pathway, responds to stimuli like cytokines or stress, directly activating transcription factors. In this cascade, p38 MAPKs phosphorylate about 200 to 300 substrates each, including downstream kinases RPS6KA5/MSK1 and RPS6KA4/MSK2, crucial for immediate-early gene induction. MAPK14 regulates protein translation, impacts cytoskeletal remodeling, participates in cellular processes, and phosphorylates transcription factors in the nucleus, modulating inflammation and chromatin dynamics. It regulates glucose uptake, skin development, erythropoiesis, and exhibits kinase-independent roles like O-Glc-N-acylation regulation. Phosphorylation activates p38 alpha/MAPK14 during UV-B irradiation and microbial infection, contributing to NLRP1 inflammasome activation and inhibiting IFN-gamma production in T-cells. p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is the recombinant human-derived p38 alpha/MAPK14 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) is 360 a.a., with molecular weight of ~43.7 kDa. |
