| Description: | IL-6 Protein, a versatile cytokine, engages in immune, regenerative, and metabolic processes by binding to IL6R, forming a complex with IL6ST/gp130. This activates the IL6-signaling pathway, initiating 'classic signaling' via membrane-bound IL6R and IL6ST, 'trans-signaling' through IL6 and soluble IL6R binding to IL6ST, and 'cluster signaling' through IL6:IL6R complexes. Essential for the acute phase response, IL-6 defends against infection and tissue injury. However, overproduction is implicated in pathology. Synthesized by myeloid cells, especially macrophages and dendritic cells, IL-6 is vital for B cell differentiation, CD4(+) T cell subsets, T follicular helper (Tfh) cells, and Th17 lineage induction. It also supports myeloma and plasmablast cell proliferation and survival. IL-6 Protein, Pig is the recombinant pig-derived IL-6 protein, expressed by E. coli, with tag free. The total length of IL-6 Protein, Pig is 184 a.a., with molecular weight of ~21.2 kDa. |
