| Description: | EGFR Protein, a receptor tyrosine kinase, binds EGF family ligands, activating multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins like GRB2. Downstream, it activates RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC, STATs, and NF-kappa-B pathways. EGFR directly phosphorylates proteins like RGS16, modulating G protein-coupled receptor signaling, and phosphorylates MUC1, enhancing its interaction with SRC and CTNNB1/beta-catenin. Notably, EGFR positively regulates cell migration through CCDC88A/GIV, promoting cell migration and contributing to learning, memory, and pain signaling. EGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of EGFR Protein, Mouse (HEK293, Fc) is 623 a.a., with molecular weight of ~142.57 kDa. |
