| Description: | B7-2/CD86 Protein, a pivotal receptor, provides the costimulatory signal crucial for T-lymphocyte proliferation and interleukin-2 production through CD28 or CTLA-4 binding. It plays a decisive role in early T-cell activation, influencing immunity or anergy within 24 hours. Additionally, B7-2/CD86 regulates B cell function, impacting IgG(1) levels. Upon CD40 engagement, it activates NF-kappa-B signaling through phospholipase C and protein kinase C activation. The protein forms homodimers, interacts with MARCH8, and engages with PHB1 and PHB2, with intensified interactions after CD40 priming. B7-2/CD86 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived B7-2/CD86 protein, expressed by HEK293, with C-6*His labeled tag. The total length of B7-2/CD86 Protein, Rabbit (HEK293, His) is 224 a.a., with molecular weight of 39-67 kDa. |
