| Description: | PDGF R alpha, a tyrosine-protein kinase, serves as a crucial cell-surface receptor for PDGFA, PDGFB, and PDGFC, influencing embryonic development, cell proliferation, survival, and chemotaxis. Its impact on cell behavior varies, promoting or inhibiting proliferation and migration based on contextual cues. Indispensable for bone marrow-derived mesenchymal stem cell differentiation, it critically contributes to skeletal development, embryonic cephalic closure, and gastrointestinal mucosa formation. PDGF R alpha's engagement activates diverse signaling cascades, phosphorylating key targets like PIK3R1 and PLCG1, triggering AKT1 pathway activation and MAP kinase and STAT family induction. Dynamic regulation involves protein phosphatases and rapid internalization to finely tune cellular responses. PDGF R alpha Protein, Human (HEK293, His) is the recombinant human-derived PDGF R alpha protein, expressed by HEK293, with C-6*His labeled tag. The total length of PDGF R alpha Protein, Human (HEK293, His) is 501 a.a., with molecular weight of ~93 kDa. |
