| Description: | Histone H4 protein serves as a core component of the nucleosome, a fundamental unit in chromatin architecture responsible for wrapping and compacting DNA, thereby restricting its accessibility to cellular machineries reliant on DNA templates. Histones, including H4, hold a central role in vital cellular processes such as transcription regulation, DNA repair, DNA replication, and maintenance of chromosomal stability. The intricate regulation of DNA accessibility involves a complex array of post-translational modifications, collectively known as the histone code, and dynamic nucleosome remodeling. The nucleosome structure comprises a histone octamer containing two H2A, H2B, H3, and H4 molecules each, organized into one H3-H4 heterotetramer and two H2A-H2B heterodimers. This octamer wraps approximately 147 base pairs of DNA. Additionally, Histone H4 participates in a co-chaperone complex with DNJC9, MCM2, and histone H3.3-H4 dimers, interacting directly with DNJC9 within the complex. Histone H4 Protein, Human/Xenopus laevis is the recombinant Xenopus laevis-derived Histone H4 protein, expressed by E. coli , with tag free. The total length of Histone H4 Protein, Human/Xenopus laevis is 102 a.a., with molecular weight of ~11.2 kDa. |
