| Description: | Leptin, a vital energy regulator, modulates appetite, metabolism, and immune responses through its central receptor, LEPR. In the hypothalamus, it reduces food intake, influences neuropeptides, and impacts bone mass and reproductive function. In peripheral tissues, Leptin enhances metabolism, regulates insulin, and exhibits pro-angiogenic effects. It activates POMC neurons, releasing anorexigenic peptides, and inhibits NPY neurons, reducing orexigenic peptides. Leptin also influences nutrient absorption, acts as a growth factor, and plays roles in apoptosis and immune responses, emphasizing its multifaceted contributions to energy balance and physiological processes. Leptin Protein, Human (His) is the recombinant human-derived Leptin protein, expressed by E. coli, with N-6*His labeled tag. The total length of Leptin Protein, Human (His) is 146 a.a., with molecular weight of ~17 kDa. |
