| Description: | Cardiac phospholamban (PLN) critically regulates ATP2A2 in the cardiac sarcoplasmic reticulum, reversibly inhibiting ATPase activity and impacting heart muscle contractility. PLN's modulation reduces ATPase affinity for Ca(2+), influencing calcium re-uptake during muscle relaxation and maintaining cardiac calcium homeostasis. The extent of ATP2A2 inhibition depends on PLN's oligomeric state, with phosphorylation alleviating inhibition. PLN's control over intracellular Ca(2+) levels in spermatids hints at a role in germ cell differentiation. As a homopentamer, PLN interacts with HAX1, ATP2A2, VMP1, and S100A1, showcasing its multifaceted regulatory functions in cellular processes. Cardiac phospholamban/PLN, Human (P.pastoris, GST) is the recombinant human-derived Cardiac phospholamban/PLN, expressed by P. pastoris, with N-GST labeled tag. The total length of Cardiac phospholamban/PLN, Human (P.pastoris, GST) is 52 a.a., with molecular weight of ~33.1 kDa. |
