| Description: | The MUSK protein, a receptor tyrosine kinase, plays a crucial role in neuromuscular junction (NMJ) formation and maintenance. Upon AGRIN recruitment by LRP4, MUSK undergoes phosphorylation and activation, influencing gene expression, orchestrating actin cytoskeleton reorganization, and clustering acetylcholine receptors (AChR) in the postsynaptic membrane. ABL1 and Src family kinases, activated by MUSK, may regulate AChR phosphorylation. The MUSK-DVL1-PAK1 ternary complex is crucial for AChR clustering. MUSK also positively regulates Rho GTPases through FNTA, mediating RAC1 activation. DNAJA3, an effector downstream of MUSK, is part of the signaling pathway. Beyond NMJ, MUSK may contribute to cholinergic responses, synaptic plasticity, and memory formation in the central nervous system. MUSK Protein, Human (P.pastoris, His) is the recombinant human-derived MUSK protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of MUSK Protein, Human (P.pastoris, His) is 472 a.a., with molecular weight of ~66 kDa. |
