| Description: | HNRNPA1 Protein intricately participates in diverse RNA processing functions, packaging pre-mRNA into hnRNP particles, facilitating poly(A) mRNA transport, and modulating splice site selection. Crucially, it repressively binds to sequences flanking PKM exon 9, favoring exon 10 inclusion in pyruvate kinase PKM splicing, resulting in the PKM M2 isoform production. Additionally, HNRNPA1 inhibits APAF1 translation by binding to the IRES and may bind specific miRNA hairpins, broadening its role in post-transcriptional gene regulation. In microbial infection, it may contribute to HCV RNA replication, highlighting its versatility in RNA metabolism and viral processes. HNRNPA1 Protein, Human (His) is the recombinant human-derived HNRNPA1 protein, expressed by E. coli, with N-6*His labeled tag. The total length of HNRNPA1 Protein, Human (His) is 353 a.a., with molecular weight of ~40.9 kDa. |
