| Description: | Coagulation Factor XII (F12), a serum glycoprotein, plays a multifaceted role in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Its involvement in these complex processes includes the cleavage of prekallikrein to form kallikrein, which subsequently cleaves Factor XII initially into alpha-factor XIIa and then, following trypsin cleavage, into beta-factor XIIa. Alpha-factor XIIa, in turn, activates factor XI to factor XIa, thereby contributing to the amplification of the coagulation cascade. Coagulation Factor XII's dynamic role in the intricate network of blood coagulation highlights its significance in orchestrating key events that ensure a balanced and regulated hemostatic response within the vascular system. Coagulation Factor XII/F12 Protein, Pig (His) is the recombinant pig-derived Coagulation Factor XII/F12 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Coagulation Factor XII/F12 Protein, Pig (His) is 352 a.a., with molecular weight of ~43.8 kDa. |
