| Description: | ATP2A2 protein, a magnesium-dependent enzyme, hydrolyzes ATP to translocate calcium from the cytosol to the sarcoplasmic reticulum. It engages in autophagy during starvation, interacting with VMP1 for ER-isolation membrane contacts. ATP2A2 modulates ER contacts with various organelles and participates in heme-stimulated mitochondrial functions. Collaborating with FLVCR2, it switches from ATP synthesis to thermogenesis. As a regulator of TNFSF11-mediated Ca(2+) signaling, ATP2A2 interacts with TMEM64, activating CREB1 and inducing mitochondrial ROS generation. These multifaceted interactions highlight ATP2A2's crucial role in cellular processes, from calcium homeostasis to autophagy and osteoclast differentiation. ATP2A2 Protein, Human (His) is the recombinant human-derived ATP2A2 protein, expressed by E. coli, with N-6*His labeled tag. The total length of ATP2A2 Protein, Human (His) is 443 a.a., with molecular weight of ~56 kDa. |
