| Description: | YAP1, a versatile transcriptional regulator, is a crucial downstream target in the Hippo signaling pathway, influencing organ size control and tumor suppression through proliferation and apoptosis modulation. Phosphorylation by STK3/MST2 and STK4/MST1, with SAV1, inactivates YAP1 and WWTR1/TAZ oncoproteins. YAP1, collaborating with TEAD transcription factors, stimulates gene expression, cell growth, and EMT induction. It inhibits ciliogenesis, acts as a transcriptional corepressor of TEAD4 target genes, and, with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. YAP1 also activates the C-terminal fragment (CTF) of ERBB4 isoform 3. YAP1 Protein, Human (P.pastoris, His) is the recombinant human-derived YAP1 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of YAP1 Protein, Human (P.pastoris, His) is 504 a.a., with molecular weight of ~68 kDa. |
