| Description: | TARDBP Protein, an RNA-binding factor with RRM1 and RRM2, binds GU-repeats, regulating RNA splicing in long introns and 3'UTRs. It impacts proteins crucial for neuronal survival and neurodegenerative diseases. TARDBP contributes to mitochondrial homeostasis, modulating mRNA stability via deadenylase recruitment. During oxidative insult, it associates with stress granules for cell survival. In skeletal muscle, TARDBP forms myo-granules, influencing sarcomeric protein mRNA. It maintains circadian clock periodicity by stabilizing CRY1 and CRY2 proteins and negatively regulates CDK6 expression. Interactions with proteins like BRDT and ATXN2 highlight diverse roles in RNA regulation and cellular processes. TARDBP Protein, Human (P.pastoris, His) is the recombinant human-derived TARDBP protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of TARDBP Protein, Human (P.pastoris, His) is 396 a.a., with molecular weight of ~44.9 kDa. |
