| Description: | The SMARCA4 Protein, a multifaceted regulator in chromatin remodeling, dynamically alters DNA-nucleosome topology through ATP-dependent enzymatic activities. As part of SWI/SNF complexes and the CREST-BRG1 complex, it modulates transcriptional processes, orchestrating calcium-dependent release of repressor complexes and activating recruitment. Crucial in neural development, SMARCA4 serves as a ZEB1 corepressor, facilitating E-cadherin transcription and contributing to diverse protein interactions. Its intricate role underscores SMARCA4's significance in cellular differentiation, chromatin dynamics, and gene expression regulation. SMARCA4 Protein, Human (P.pastoris, His) is the recombinant human-derived SMARCA4 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of SMARCA4 Protein, Human (P.pastoris, His) is 547 a.a., with molecular weight of ~64.8 kDa. |
