| Description: | C1QA protein is instrumental in forming C1, the initiating component of the serum complement system. C1q associates with proenzymes C1r and C1s, leading to C1 assembly. The collagen-like regions of C1q engage with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex. Efficient C1 activation occurs when the globular heads of C1q interact with the Fc regions of IgG or IgM antibodies within immune complexes. Active C1 forms a calcium-dependent trimolecular complex (C1q, C1r, and C1s) in a 1:2:2 molar ratio, with C1q comprising nine subunits�six disulfide-linked dimers of A and B chains, and three disulfide-linked dimers of the C chain. Additionally, C1QA, via its C-terminus, interacts with CD33, activating CD33 inhibitory motifs. C1QA Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived C1QA protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of C1QA Protein, Mouse (P.pastoris, His) is 223 a.a., with molecular weight of ~25.6 kDa. |
