| Description: | The NLRP3 protein serves as the sensor in the NLRP3 inflammasome, activating in response to membrane defects caused by pathogens or damage signals. It assembles the inflammasome complex, including NLRP3, CASP1, and PYCARD/ASC. Caspase-1 activation leads to the cleavage of IL1B, IL18, and GSDMD, resulting in cytokine secretion and pyroptosis. Various stimuli, such as ATP, nigericin, and crystals, trigger NLRP3 activation by inducing K(+) efflux and membrane perturbation. NLRP3, interacting with NEK7, relocates to trans-Golgi network vesicle membranes, forming an active inflammasome. Additionally, NLRP3 influences T helper 2 cell differentiation, impacting processes like asthma and tumor growth. NLRP3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived NLRP3 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of NLRP3 Protein, Mouse (His-SUMO) is 153 a.a., with molecular weight of ~35 kDa. |
