| Description: | UBE2A, collaborating with the E3 enzyme BRE1, facilitates ubiquitin attachment to proteins, specifically histone H2B at 'Lys-120,' forming H2BK120ub1. This modification serves as a tag for transcriptional activation, RNA polymerase II elongation, telomeric silencing, and is essential for H3K4me and H3K79me formation. UBE2A, involved in 'Lys-11' and 'Lys-48'-linked polyubiquitination in vitro, is crucial for postreplication repair of UV-damaged DNA. UBE2A Protein, Human (GST-His) is the recombinant human-derived UBE2A protein, expressed by E. coli, with N-6*His, N-GST labeled tag. The total length of UBE2A Protein, Human (GST-His) is 152 a.a., with molecular weight of ~52.0 kDa. |
