| Description: | Siglec-8 Protein, a putative adhesion molecule, mediates sialic-acid dependent binding to red blood cells, preferring alpha-2,3-linked sialic acid and interacting with alpha-2,6-linked sialic acid. Its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. Moreover, it simultaneously recognizes epitopes featuring a terminal N-acetylneuraminic acid and an underlying 6-O-sulfated galactose, with specific affinity for Gal-6-sulfated sialyl-Lewis X glycan epitopes. Siglec-8 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-8 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Siglec-8 Protein, Human (HEK293, His) is 347 a.a., with molecular weight of 40-60 kDa. |
