| Description: | MAP1LC3B, a key ubiquitin-like modifier, crucially shapes autophagosomal vacuoles, maintaining cellular homeostasis. In mitophagy, it regulates mitochondrial quantity, curbing reactive oxygen species and ensuring energy efficiency. Binding C-18 ceramides during stress anchors autophagolysosomes to outer mitochondrial membranes, aiding damaged mitochondria elimination. As part of the GABARAP/GATE-16 subfamily, it aids later-stage autophagosome maturation, promotes ciliogenesis, remodels ER into autophagosomes via TEX264, and recruits cofactor JMY during nutrient stress, enhancing actin nucleation and autophagosome biogenesis. Interacting with SQSTM1, ATG13, MAPK15, BNIP3, KEAP1, PCM1, and TBC1D5, MAP1LC3B demonstrates versatile involvement in diverse cellular processes and signaling pathways. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli, with tag free. The total length of MAP1LC3B Protein, Human is 125 a.a., with molecular weight of ~16.15 kDa. |
