| Description: | Enterotoxin type B Protein is the prototype of a non-enterotoxin gene cluster (egc)-associated potent superantigen (SAg). SEB cross-links Ag-presenting cells (APCs) and T cells by forming a ternary complex between the immune receptors major histocompatibility complex (MHC) class II and specific Vβ chains of the T-cell receptors (TcR). SEB is excreted by S. aureus strains from diverse clonal complexes. SEB is a potent T cell stimulant. SEB activates Toll Like Receptor 2 and triggers the production of pro-inflammatory cytokines; furthermore, it induces reactive oxygen species and endoplasmic reticulum stress-induced inflammation that may cause epithelial cell integrity disruption and enhance their permeability[1][2][3]. EpCAM/TROP1 Protein, Human (HEK293, His) is the recombinant human-derived EpCAM/TROP1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of EpCAM/TROP1 Protein, Human (HEK293, His) is 242 a.a., with molecular weight of approximately 34-42 kDa. |
