| Description: | MCR-1 Protein likely catalyzes adding a phosphoethanolamine moiety to lipid A, associated with polymyxin resistance. This modification, seen in E. coli expressing MCR-1, increases minimal inhibitory concentrations (MIC) of colistin and polymyxin B. The pHNSHP45 plasmid, carrying the mcr-1 gene, efficiently transfers to other E. coli strains, significantly elevating polymyxin MIC. Resistance, demonstrated in K. pneumoniae and P. aeruginosa, is maintained without selective pressure. In a murine study, an mcr-1-encoding plasmid provides in vivo protection against colistin, emphasizing MCR-1's crucial role in polymyxin resistance across bacterial strains. MCR-1 Protein, E.coli (Cell-Free, His-SUMO) is the recombinant E. coli-derived MCR-1 protein, expressed by E. coli Cell-free. The total length of MCR-1 Protein, E.coli (Cell-Free, His-SUMO) is 541 a.a., the molecular weight are 80 KDa (monomer), 160 KDa (dimer), whiel dimers are generally formed. |
