| Description: | Apolipoprotein E (APOE) plays a pivotal role in lipoprotein-mediated lipid transport, acting as a core component in plasma lipoproteins' production, conversion, and clearance. As an amphipathic molecule, APOE associates with various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. It engages with cellular receptors, such as LDLR, LRP1, LRP2, LRP8, and VLDLR, facilitating cellular uptake of APOE-containing lipoproteins. APOE's functions include mediating lipoprotein clearance, participating in biosynthesis, and uptake of VLDLs by peripheral tissues for triglyceride delivery, contributing to lipid homeostasis, reverse cholesterol transport, and playing diverse roles in the central nervous system, immune responses, and transcriptional regulation. Apolipoprotein E/APOE Protein, Human (HEK293, C-His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293, with C-6*His labeled tag. The total length of Apolipoprotein E/APOE Protein, Human (HEK293, C-His) is 298 a.a., with molecular weight of ~36.36 kDa. |
