| Description: | TGFB1 Proprotein, precursor to Latency-associated peptide (LAP) and active Transforming Growth Factor Beta-1 (TGF-beta-1) chains, maintains TGF-beta-1 latency in the extracellular matrix. TGFB1 associates non-covalently with TGF-beta-1, regulating its activation via interactions with 'milieu molecules' (LTBP1, LRRC32/GARP, LRRC33/NRROS). LRRC33/NRROS interaction controls TGF-beta-1 activation in macrophages and microglia, while LRRC32/GARP regulates activation on activated regulatory T-cells (Tregs). Additionally, TGFB1 interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) distorts the Latency-associated peptide chain, releasing active TGF-beta-1. Animal-Free TGF beta 1/TGFB1 Protein, Pig (His) is the recombinant pig-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free TGF beta 1/TGFB1 Protein, Pig (His) is 112 a.a., with molecular weight of ~13.7 kDa. |
