| Description: | TGF beta-1/TGFB1 Protein, in its proprotein form, acts as a precursor for both Latency-associated peptide (LAP) and active Transforming growth factor beta-1 (TGF-beta-1) chains. Crucial for maintaining TGF-beta-1 in a latent state within the extracellular matrix, the proprotein interacts with 'milieu molecules' such as LTBP1, LRRC32/GARP, and LRRC33/NRROS, regulating TGF-beta-1 activation. LRRC33/NRROS activates TGF-beta-1 in macrophages and microglia, while LRRC32/GARP controls its activation on activated regulatory T-cells (Tregs). Additionally, the proprotein interacts with integrins (ITGAV:ITGB6 or ITGAV:ITGB8), distorting the Latency-associated peptide chain and releasing active TGF-beta-1. Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His) is 112 a.a., with molecular weight of ~13.8 kDa. |
